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Introduction

Monitoring PFAS in biological samples like fish and animal tissue is essential for food safety and environmental risk assessment, but it presents unique challenges due to complex matrices and variable recoveries. Part 4 of this 4-part application note series demonstrates a validated sample prep and LC-MS/MS workflow tailored to meet these challenges while complying with US EPA Method 1633.

Using alkaline digestion followed by SPE cleanup and analysis on the PerkinElmer QSight® 500 LC/MS/MS system, this method delivers reproducible and reliable detection of 40 PFAS compounds across a variety of tissue types, including tilapia, shrimp, salmon, and pork. The approach ensures low detection limits and high recovery rates, supporting both regulatory compliance and operational efficiency.

  • Tissue-specific workflow validated using certified reference materials
  • Meets EPA Method 1633 targets for recovery and precision
  • Optimized for food safety labs, environmental testing, and government agencies

Download Part 4 to explore complete protocols, recovery data, and matrix-specific insights — closing out the full PFAS testing series.

 

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